Alzheimer’s Disease (AD) is an unfortunate neurodegenerative condition without a cure, which poses a challenge as its prevalence continues to increase. Researchers are trying to find better treatments by looking at natural and synthetic counterparts.
Some clinical trials highlight the significant potential of serotonergic psychedelics, including LSD, DMT, and psilocybin, in the treatment of Alzheimer’s disease. For more interesting information, you can explore online sources or opt to “buy psychedelics online Canada.”
Table of Contents
Psychedelics in Alzheimer’s Treatment
Classic psychedelics show assurance in treating early-stage Alzheimer’s Disease (AD) or mild cognitive impairment (MCI) by stimulating brain cell growth.
By targeting specific receptors in the brain, psychedelics may trigger neural plasticity for learning and memory. This could slow down or even reverse the neurodegenerative effects of AD. Also, psychedelics may ease depression and anxiety, common in AD patients, by promoting positive psychological effects.
Questions remain about how psychedelic treatments work. Some believe that experiencing intense effects from high-dose psychedelics, such as mystical feelings or a sense of losing oneself, is important for reaping psychological benefits. Meanwhile, others argue that the key lies in the biological changes these substances induce. Both viewpoints may be correct.
Classic psychedelics appear to help the brain adapt and reduce inflammation, even at lower doses. So, low-dose treatments might help conditions like brain degeneration or migraines without strong effects on the mind. But for depression, anxiety, or addiction, the mind-altering effects seem important, leading to insights and changes in behaviour. Studying both low and high doses is important for personalized therapy.
What Does Serotonergic Psychedelics Do?
Serotonergic psychedelics, including LSD (lysergic acid diethylamide), DMT (dimethyltryptamine), and psilocybin (found in magic mushrooms), have garnered increasing attention for their potential therapeutic effects on various mental health conditions.
Scholars stated that serotonin receptors, known for their pro-cognitive and neuroplasticity-modulating capabilities, offer promising avenues in AD research.
These substances exert their pharmacological effects primarily by modulating the serotonin system in the brain. Thus leading to alterations in perception, mood, and consciousness. Here are claims from different studies supporting this idea:
- The receptors, particularly the 5-HT2A subtype, influence gene expression of neuroplasticity-enhancing neurotrophins in brain regions affected by AD.
- These receptors fine-tune cortical signalling (important for cognition, memory, and synaptic plasticity).
- Despite their atypical distribution within neurons, serotonin receptors play a role in neural development, regeneration, and plasticity.
Remarkable Study Findings
- Serotonergic psychedelics have shown potential in addressing aspects of AD pathology by promoting neuroplasticity.
- Classic psychedelics influence neurotransmission, promote synaptic remodelling, and up-regulate factors supporting neuronal survival.
- Certain psychedelics, like muscimol and Sig-1R agonists, may reduce the neurotoxicity associated with AD progression.
- Classic psychedelics activate pathways in brain regions affected by AD, suggesting potential for slowing or reversing brain degeneration.
- Psilocybin mushrooms induce neural plasticity to promote neurogenesis and facilitate long-lasting changes in brain circuits.
- Psychedelics enhance brain connectivity by targeting receptor genes and inducing changes in neurons and networks.
The clinical research conducted has shown that both classic and non-classic psychedelics from magic mushrooms impact various biological processes in the brain. These effects include rapid changes in gene expression and big changes in brain structure and function.
These psychedelics interact with receptors like serotonin, sigma, NMDA, and GABA, leading to improved synaptic plasticity and brain restoration. So, psychedelics could have positive effects on behaviour, memory, and cognition, which makes them promising prospects for treating AD and related disorders.
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- LSD
LSD is a man-made drug derived from a fungus called ergot found on rye grains. It’s a psychoactive substance that can change perceptions, feelings, and thoughts, even in small amounts.
Taking too much LSD can lead to strong hallucinations, disrupting your sense of time and space. Be cautious, as substances sold as LSD might be other drugs like NBOMe or members of the 2C drug family.
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| Dosage | 50mg per troche / 30 per pack – 1.5 grams ketamine/ per pack | Total 600ug/6 Tabs (100ug/Tab) | Total 200ug/2 Gummies (100ug/Gummy) |
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- Shrooms
Over 180 types of mushrooms contain psilocybin and psilocin, which are known for their therapeutic properties and positive impact on mental health.
Effects vary depending on the mushroom strain, batch, amount consumed, and individual tolerance levels. Some prefer microdosing for mild effects, while others take larger amounts for a deeper experience. Quality also varies based on cultivation methods.
Blue Meanies, or Panaeolus cyanescens, are small dried mushrooms that grow in warm tropical areas, usually on cow and water buffalo dung. As they grow older, they develop blue flakes on their surface, which gives them their name.
- These mushrooms possess psilocybin and psilocin, which are high in concentration.
- They’ve been used recreationally for a long time, especially by the people of Bali, who use them during festivals and for inspiration in art.
- They’re popular among travellers and tourists in Bali and similar places because of their hallucinogenic effects. These effects can include euphoria, hallucinations, happiness, and intense laughter.
- DMT
DMT is a potent hallucinogenic drug found in certain plants like Psychotria viridis and Chacruna. Also known as the “spirit molecule,” these controlled substances can produce intense psychedelic experiences. It offers a short but deeply immersive journey with vivid visual and auditory hallucinations.
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| DMT Content | 1g | Approximately 90mg | 1ml |
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| Effects | Intense hallucinations, altered consciousness. | Visual psychedelic experience, longer duration. | Spiritual insight, euphoria, radical perspective shifts. |
| Duration | Varies | Up to 1 hour | Up to 30 minutes |
Long-Term Effects Associated with Psychedelic Use
Ongoing research is looking into what happens over time when people use psychoactive substances. We’re still learning a lot about this. Long-term effects mean any changes in how you think, feel, or remember things that might stick around after using psychedelics for a while.
Studying the long-term effects of psychedelics is complicated. Some studies show that they might help with mental health problems, but others say they could make things worse, like causing psychosis.
Even though it’s challenging, scientists are still trying to figure out what using psychedelics for a long time might mean for your mental health. They’re doing careful studies that follow people over many years to get a better idea.
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The study suggests that psychedelics might greatly change the way we treat Alzheimer’s disease. This marks a big shift in our approach to brain disorders. Researchers think that using these drugs for therapy could change Alzheimer’s treatment completely, bringing hope to many people and their families.
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Frequently Asked Questions
How do psychedelics differ from other substances commonly used in Alzheimer’s treatments?
Psychedelics, studied for their medical use, differ from traditional Alzheimer’s drugs in their treatment method and effects. They target the brain’s serotonin system to stimulate new neural connections and offer profound psychological experiences beneficial for emotional well-being.
Unlike standard medications focused on symptom management, psychedelics are under review by Health Canada for their lasting benefits and holistic treatment approach, which includes therapy.
Research into psilocybin use for conditions like obsessive compulsive disorder and its safety profile in avoiding multi system organ failure distinguishes it from controlled drugs in conventional treatments.
Can psychedelic-assisted therapy be considered a viable treatment option for Alzheimer’s patients experiencing end-of-life distress?
Psychedelic-assisted therapy could help Alzheimer’s patients who are very sick and feeling distressed about the end of their lives.
- It can make people feel better emotionally. This therapy has helped some people feel less anxious and sad, especially those who are very sick. It might do the same for Alzheimer’s patients.
- It’s commonly safe with guidance. When done in a safe place with a therapist, using psychedelics like this doesn’t usually cause harm, and most people handle it well.
- It could improve life quality. For someone with Alzheimer’s, feeling better emotionally can make a big difference, even if their memory problems don’t improve.
- We need to learn more. Although it sounds promising, we need more research to make sure this therapy is safe and works well for Alzheimer’s patients, especially those nearing the end of their lives.
How long does a psychedelic therapy session for Alzheimer’s patients last?
- Preparation Phase. This involves one or two meetings that last about 1 to 2 hours each. These sessions help prepare the patient for the experience, discussing expectations and building trust with the therapist.
- Psychedelic Session Day. The key session, where the patient takes the psychedelic substance, commonly lasts 4 to 6 hours. During this time, the patient is in a controlled setting, usually lying down with eye shades and listening to music, under the close supervision of therapists.
- Integration Phase. After the session, follow-up meetings are held to help the patient process and integrate their experience. These meetings are usually 1 to 2 hours long each and can vary in number.
References:
- https://www.sciencedirect.com/science/article/pii/S0924977X23001347#sec0011
- https://mindmedicineaustralia.org.au/wp-content/uploads/PsychedelicsAlzheimersReviewFinal2021-1.pdf
Author Information
Michael James Winkelman, Attila Szabo, and Ede Frecska; Albert Garcia-Romeu, Sean Darcy, Hillary Jackson, Toni White, and Paul Rosenberg.
Affiliations:
- School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, United States.
- Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
- KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.
- Department of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
- Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- Memory and Alzheimer’s Treatment Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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