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Magic mushrooms have recently garnered attention for their ability to treat various mental health disorders, particularly depression. One approach gaining traction involves consuming a standard dose of approximately 25 mg of the active compound, available at a mushroom dispensary. This dosage is promising in providing relief and could complement conventional depression treatments.

A group of scholars found that psilocybin, the active ingredient in a magic mushroom, provided promising results in treating depression.

Key Takeaways:

  • Psilocybin shows improvement in depression symptoms within eight days only.
  • The side effects of psilocybin are well-tolerated and are often mild to moderate.
  • A 25mg psilocybin can alter perception, mood shifts, heightened creativity, and a feeling of unity.

A Single Dose is All You Need

A current study adopts a strict approach. Employing a randomized, multiblinded design, it compared a single dose of psilocybin with an active placebo (niacin). The study investigated the onset of action, benefit duration, and safety profile of psilocybin over six weeks.

The Participants

The study looked for persons between the ages of 21 and 65 who met the criteria for Major Depressive Disorder (MDD) as listed in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) and who were going through a depressive episode that lasted for at least 60 days at the time.

The Process

Participants received a single 25-mg oral dose of psilocybin or a 100-mg dose of niacin. Niacin served as an active placebo, which elicited an acute physiological response (flushing) aimed at maintaining blinding integrity.

Both psilocybin and niacin placebo administrations followed a standardized “set and setting” protocol. The preparatory sessions lasted 6 to 8 hours with two facilitators, and the dosing session lasted 7 to 10 hours in a comfortable environment. Participants reflected on their experience four hours after taking the dose.

What the Researchers Found

Improvements in depression were evident within just eight days of administering psilocybin. This positive effect persisted without diminishing throughout the 6-week follow-up period. It exhibited higher rates of Montgomery-Asberg Depression Rating Scale (MADRS) score-defined response and remission compared to other psilocybin studies on Treatment-Resistant Depression.

Psilocybin showed enhanced psychosocial functioning in comparison to niacin. Treatment with psilocybin gave promising results in several areas, such as reduced overall disease severity, anxiety, self-reported depressive symptoms, and an enhanced quality of life.

Most people tolerated the compound well, experiencing only mild or moderate side effects, mainly during the initial dosing phase. However, psilocybin treatment had more frequent and severe side effects than niacin, which matches what we know about its effects. 

The researchers noted that psychedelics like psilocybin might cause side effects that standard rating scales don’t always catch or could reveal psychiatric conditions that were previously unnoticed, even as they effectively treat specific syndromes.

What Does a 25-mg Dose Mean?

A standard psychedelic dose ranges from 15 to 25 milligrams of psilocybin (1.5 to 2.5 grams of dried shrooms). It’s what most people consume when they want to experience the true psychedelic effects of magic mushrooms.

It’s a gateway to altered perception, mood shifts, heightened creativity, and a feeling of unity with your environment. While you might encounter subtle visual effects, intense hallucinations are rare. Entering it feels like stepping into a vibrant dreamscape where reality smoothly blends into a captivating mix of sights and sounds.

The euphoria often finds expression through dance, gentle sways, or simply surrendering to the psychedelic symphony. The trip lasted approximately 4 to 8 hours. At this level, visual distortions may become more pronounced. Patterns dance and morph, and your surroundings pulsate with energy.

You can manage this dosage, but it requires a controlled environment and a confident mindset. It promises an odyssey filled with awe and wonder, which invites you to explore consciousness with steady steps.

  • A more noticeable improvement in colour.
  • Aberrations in vision, such as shifting or “breathing” things.
  • Synesthesia (e.g., “seeing sounds” or “hearing colours”).
  • A deeper comprehension of music.
  • Laughing
  • Alterations to tactile perception.
  • Self-reflection
  • Euphoria
  • Time distortion
  • Increase heart rate and blood pressure.

What to Consume from Magic Mushroom Stores

Magic mushroom dispensaries sell multiple products containing psilocybin. These shops offer various options, including dried mushrooms, edibles, capsules, drinks, and more. Dried mushrooms are particularly prevalent. 

Health Canada recognizes over 200 species of magic mushrooms, with Psilocybe cubensis being a commonly offered variant. This strain comes in multiple varieties, which ensures a diverse selection for consumers. The experience is like browsing the choices available at cannabis dispensaries.

Other Shroom Products:

EdiblesFood products (gummies and chocolates) containing psilocybin.
Dosing is easy because the manufacturers already include the amount per piece.
CapsulesThey’re tasteless, and you can seamlessly add to your wellness routine. 
They feature only minimal amounts to ensure a subtle addition to your regimen.
DrinksLike edibles but in the form of beverages.
They’re versatile and come in the form of chocolate, coffee, or tea.

Find Your Dose in Magic Mushroom Dispensaries

Although using magic mushrooms remains uncommon for treating depression, Canada has taken a progressive step forward. They’ve authorized the testing and medical use of psilocybin, classified as a Schedule I substance under the Controlled Drugs and Substances Act, for specific patients grappling with complex major depressive disorder. This move could potentially benefit tens of thousands who experience anxiety and depression, as they have seized tens of opportunities for alternative treatments through clinical trials.

Frequently Asked Questions

Can I buy psilocybin from a medicinal mushroom dispensary?

Most medicinal mushroom dispensaries feature products such as Reishi, Turkey Tail, or Lion’s Mane. For those seeking to explore the world of mushrooms, an online magic mushroom dispensary could be your destination. These dispensaries specialize in a variety of mushroom products, like dried mushrooms and other psychedelics.

Can I only consume 25 mg for depression treatment?

Studies are delving into alternative dosages of psilocybin for the treatment of depression. Certain research works concentrated on low doses, while others have investigated higher quantities of psilocybin. A potential approach could involve initiating a microdose and gradually exploring higher dosages.

Can I buy shrooms in Toronto?

Online mushroom retailers offer customers the convenience of purchasing from anywhere in Canada. Regardless of your province or city, these online stores ensure delivery to your location.

What is the cheapest product I can find in an online mushroom shop?

Dried mushrooms are the most common product people purchase due to the variety of available quantities. The pricing can fluctuate if you need as little as 1 gram or prefer to buy in bulk. While edibles and other items are reasonably priced, they may not offer the same cost-effectiveness as dried mushrooms.

Will a single intake of shrooms be enough to heal from depression?

Some studies suggest that a single dose may effectively alleviate depression symptoms. It’s important to recognize that participants in these studies still engaged in talk therapy alongside treatment. Psychedelic therapy integration with therapeutic sessions appears to yield optimal results.

Author Information

Charles L. Raison et al.; Jeremy D. Coplan, MD and Dorothy P. Reddy, MD; Albert Garcia-Romeu, Frederick S Barrett, Theresa M Carbonaro, Matthew W Johnson, and Roland R Griffiths; Vince Polito and Richard J. Stevenson; Rebecca Smausz, Joanna Neill, and John Gigg.


  • Usona Institute, Fitchburg, Wisconsin
  • SUNY Downstate Medical Center, Brooklyn, New York
  • Neurogenesis Clinics, Brooklyn, New York
  • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA
  • Department of Cognitive Science, Macquarie University, Sydney, Australia
  • Department of Psychology, Macquarie University, Sydney, Australia
  • Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
  • Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
  • Medical Psychedelics Working Group, Drug Science, UK

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