A 2024 case report highlights how a 41-year-old woman reported relief from persistent Long COVID symptoms after using psilocybin mushrooms. The woman experienced improvements in symptoms such as fatigue, anxiety, depression, headaches, brain fog, and joint pain following guided psychedelic-assisted sessions involving psilocybin and MDMA. Researchers noted that her case may provide insights into how psychedelics could influence mental health and other long-term symptoms associated with post-COVID conditions.
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What Happened in the Post-COVID Psilocybin Case Study?
A case study published in Clinical Case Reports (Open Access) is about a 41-year-old woman who had been healthy before catching the virus in February 2022 and developing severe post-COVID. She received vaccination three times, yet she still experienced several indicators, such as:
- Cognitive struggles
- Intense anxiety
- Depression
- Insomnia
- Joint pain
- Headache
Physical therapy, fasting, and meditation have worked so little that she sought the help of psychedelics under a controlled session with a therapist. A dose of 1 gram was her starting point. After a week, she reported a 20% improvement in symptoms. After more than a month, she took her second session at a higher dose and combined it with MDMA in the form of tea.
The succeeding session brought bigger improvements in her situation. It decreased her symptoms and improved her sense of well-being. It also enhanced her cognitive function, which enabled her to resume her PhD studies and return to work.
How Psilocybin May Influence Post-COVID Symptoms
Researchers are exploring whether psilocybin may influence some symptoms associated with post-COVID, including anxiety, depression, fatigue, and cognitive difficulties.
Mental Health Symptoms
Post-COVID syndrome can affect mental health, with some individuals experiencing ongoing anxiety, depression, emotional distress, and difficulty coping with changes after infection.
A study published in Nature Communications examined how a single dose of psilocybin affected brain activity and psychological outcomes in healthy adults with no previous psychedelic experience.
Researchers found that psilocybin increased brain entropy, a measure of more diverse and flexible brain activity, which was associated with greater psychological insight and improved well-being in the following weeks.
The findings suggest that psilocybin may influence patterns of thinking and emotional processing by promoting greater flexibility in brain function.
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Brain Fog and Cognitive Function
Brain fog, memory problems, and difficulty concentrating are commonly reported after COVID-19 infection. Researchers are examining whether psilocybin’s effects on neuroplasticity, or the brain’s ability to adapt and form new connections, may have relevance for these cognitive symptoms.
Recent research published in Nature Neuroscience has explored how psilocybin may influence brain connectivity and the growth of neural connections. In a mouse study, researchers found that psilocybin increased dendritic spine growth, which are small structures that help brain cells communicate. The findings suggest that psilocybin may promote changes in brain circuits linked to learning, mood, and adaptation.
Inflammation
Inflammation and immune system changes are believed to contribute to some post-COVID symptoms, including fatigue, pain, and cognitive difficulties. Because psilocybin interacts with serotonin receptors found throughout the body, researchers are investigating whether it may influence inflammatory processes beyond its effects on the brain.
Other Post-COVID Experiences With Psilocybin
Beyond individual case reports, researchers have also examined online accounts from people with post-COVID symptoms who reported using psilocybin. A research article in the Journal of Psychoactive Drugs analyzed discussions from Reddit communities focused on long COVID to explore how individuals described their experiences with psychedelic mushrooms.
The study reviewed 110 posts from people who reported both post-COVID neuropsychiatric symptoms and psilocybin use. The most commonly reported symptoms included:
| Symptom | Percentage |
|---|---|
| Fatigue | 47.3% |
| Cognitive difficulties or brain fog | 46.4% |
| Depression | 30% |
Among the posts analyzed, 78.2% of users reported some level of improvement in their post-COVID symptoms after using psilocybin. Among those who experienced improvements, most reported that the effects lasted beyond the immediate psychedelic experience.
Order Safe and Quality Shrooms Online
The case of a 41-year-old woman highlights the growing interest in psilocybin research and its potential connection to post-COVID symptom management. Her reported improvements in fatigue, brain fog, anxiety, depression, and joint pain after psychedelic-assisted sessions have encouraged further discussion about how psilocybin may influence mental health, brain function, and inflammation-related pathways.
However, current research on psilocybin and post-COVID symptoms remains in its early stages. Existing evidence includes case reports, online self-reported experiences, and studies exploring related mechanisms such as serotonin activity, neuroplasticity, and immune response. These findings are preliminary and do not establish psilocybin as a treatment for post-COVID symptoms.
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Frequently Asked Questions
Can psilocybin help with anosmia after COVID?
A case report from the Journal of Psychoactive Drugs found that a woman with COVID-19-related anosmia reported improvement in her sense of smell after microdosing psilocybin mushrooms three times. Researchers suggested that psychedelics may influence olfactory recovery through possible mechanisms involving serotonin activity, neuroplasticity, and anti-inflammatory effects.
Can magic mushrooms provide lasting effects for post-COVID symptoms after the trip?
In the reported post-COVID case study, the woman experienced improvements that continued beyond the immediate psychedelic experience. After her psilocybin sessions, she reported reduced symptoms, improved cognitive function, and better overall well-being.
Does psilocybin help with insomnia caused by post-COVID symptoms?
There is currently no direct study showing that psilocybin treats post-COVID insomnia. However, an article from Translational Psychiatry examined psilocin (the active metabolite of psilocybin) and found that it temporarily affected sleep patterns and brain activity, including changes in REM sleep and sleep regulation mechanisms. These findings suggest that psychedelic compounds may influence brain processes involved in sleep, mood, and neural activity, but they do not establish psilocybin as a treatment for insomnia.